Study
Transcriptomes of human CD4+ T lymphocytes - Metabolic project
| Study ID | Alternative Stable ID | Type |
|---|---|---|
| EGAS00001005565 | Other |
Study Description
Human CD4+ T cells are essential mediators of immune responses. By altering the mitochondrial and metabolic states, we defined metabolic requirements of human CD4+ T cells for in vitro activation, expansion, and effector function. T cell activation and proliferation were reduced by inhibiting oxidative phosphorylation, while early cytokine production was maintained by either OXPHOS or glycolytic activity. Glucose deprivation in the presence of mild mitochondrial stress markedly reduced all three T cell functions, contrasting the exposure to resveratrol, an antioxidant and sirtuin-1 activator, which specifically inhibited cytokine production and T cell proliferation, but not T cell activation. Conditions that inhibited T cell activation were associated with the downregulation of 2′,5′-oligoadenylate synthetase genes via interferon response pathways. Our findings indicate that T cell function is grossly impaired by stressors combined with nutrient deprivation, suggesting that correcting nutrient availability, metabolic stress and/or the function of T cells in these conditions will ... (Show More)
Study Datasets 54 datasets.
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
| Dataset ID | Description | Technology | Samples |
|---|---|---|---|
| EGAD00001008037 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008038 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008039 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008040 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008041 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008042 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008043 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008044 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008045 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008046 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008047 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008048 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008049 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008050 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008051 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008052 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008053 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008054 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008055 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008056 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008057 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008058 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008059 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008060 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008061 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008062 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008063 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008064 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008065 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008066 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008067 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008068 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008069 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008070 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008071 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008072 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008073 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008074 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008075 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008076 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008077 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008078 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008079 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008080 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008081 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008082 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008083 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008084 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008085 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008086 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008087 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008088 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008089 |
NA
|
Illumina HiSeq 2500 | 1 |
| EGAD00001008090 |
NA
|
Illumina HiSeq 2500 | 1 |
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