Study

Transcriptomes of human CD4+ T lymphocytes - Metabolic project

Study ID Alternative Stable ID Type
EGAS00001005565 Other

Study Description

Human CD4+ T cells are essential mediators of immune responses. By altering the mitochondrial and metabolic states, we defined metabolic requirements of human CD4+ T cells for in vitro activation, expansion, and effector function. T cell activation and proliferation were reduced by inhibiting oxidative phosphorylation, while early cytokine production was maintained by either OXPHOS or glycolytic activity. Glucose deprivation in the presence of mild mitochondrial stress markedly reduced all three T cell functions, contrasting the exposure to resveratrol, an antioxidant and sirtuin-1 activator, which specifically inhibited cytokine production and T cell proliferation, but not T cell activation. Conditions that inhibited T cell activation were associated with the downregulation of 2′,5′-oligoadenylate synthetase genes via interferon response pathways. Our findings indicate that T cell function is grossly impaired by stressors combined with nutrient deprivation, suggesting that correcting nutrient availability, metabolic stress and/or the function of T cells in these conditions will ... (Show More)

Study Datasets 54 datasets.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001008037
NA
Illumina HiSeq 2500 1
EGAD00001008038
NA
Illumina HiSeq 2500 1
EGAD00001008039
NA
Illumina HiSeq 2500 1
EGAD00001008040
NA
Illumina HiSeq 2500 1
EGAD00001008041
NA
Illumina HiSeq 2500 1
EGAD00001008042
NA
Illumina HiSeq 2500 1
EGAD00001008043
NA
Illumina HiSeq 2500 1
EGAD00001008044
NA
Illumina HiSeq 2500 1
EGAD00001008045
NA
Illumina HiSeq 2500 1
EGAD00001008046
NA
Illumina HiSeq 2500 1
EGAD00001008047
NA
Illumina HiSeq 2500 1
EGAD00001008048
NA
Illumina HiSeq 2500 1
EGAD00001008049
NA
Illumina HiSeq 2500 1
EGAD00001008050
NA
Illumina HiSeq 2500 1
EGAD00001008051
NA
Illumina HiSeq 2500 1
EGAD00001008052
NA
Illumina HiSeq 2500 1
EGAD00001008053
NA
Illumina HiSeq 2500 1
EGAD00001008054
NA
Illumina HiSeq 2500 1
EGAD00001008055
NA
Illumina HiSeq 2500 1
EGAD00001008056
NA
Illumina HiSeq 2500 1
EGAD00001008057
NA
Illumina HiSeq 2500 1
EGAD00001008058
NA
Illumina HiSeq 2500 1
EGAD00001008059
NA
Illumina HiSeq 2500 1
EGAD00001008060
NA
Illumina HiSeq 2500 1
EGAD00001008061
NA
Illumina HiSeq 2500 1
EGAD00001008062
NA
Illumina HiSeq 2500 1
EGAD00001008063
NA
Illumina HiSeq 2500 1
EGAD00001008064
NA
Illumina HiSeq 2500 1
EGAD00001008065
NA
Illumina HiSeq 2500 1
EGAD00001008066
NA
Illumina HiSeq 2500 1
EGAD00001008067
NA
Illumina HiSeq 2500 1
EGAD00001008068
NA
Illumina HiSeq 2500 1
EGAD00001008069
NA
Illumina HiSeq 2500 1
EGAD00001008070
NA
Illumina HiSeq 2500 1
EGAD00001008071
NA
Illumina HiSeq 2500 1
EGAD00001008072
NA
Illumina HiSeq 2500 1
EGAD00001008073
NA
Illumina HiSeq 2500 1
EGAD00001008074
NA
Illumina HiSeq 2500 1
EGAD00001008075
NA
Illumina HiSeq 2500 1
EGAD00001008076
NA
Illumina HiSeq 2500 1
EGAD00001008077
NA
Illumina HiSeq 2500 1
EGAD00001008078
NA
Illumina HiSeq 2500 1
EGAD00001008079
NA
Illumina HiSeq 2500 1
EGAD00001008080
NA
Illumina HiSeq 2500 1
EGAD00001008081
NA
Illumina HiSeq 2500 1
EGAD00001008082
NA
Illumina HiSeq 2500 1
EGAD00001008083
NA
Illumina HiSeq 2500 1
EGAD00001008084
NA
Illumina HiSeq 2500 1
EGAD00001008085
NA
Illumina HiSeq 2500 1
EGAD00001008086
NA
Illumina HiSeq 2500 1
EGAD00001008087
NA
Illumina HiSeq 2500 1
EGAD00001008088
NA
Illumina HiSeq 2500 1
EGAD00001008089
NA
Illumina HiSeq 2500 1
EGAD00001008090
NA
Illumina HiSeq 2500 1

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