Study

Genomics to select patients with metastatic breast cancer for targeted therapy (microarray cytoscan)

Study ID Alternative Stable ID Type
EGAS00001005584 Other

Study Description

Cancer progression is driven in part by genomic alterations located in oncogenes or tumor suppressor genes. The genomic characterization of cancers has shown a large interpatient heterogeneity regarding the driver alterations, leading to the concept that generating a genomic profiling by multigene sequencing in patients with cancer could allow selecting effective targeted therapies. While this concept has been broadly implemented in daily practice, there is no evidence that such approach improves patient outcome, and how to optimally select the therapy to administer. A genomic profiling using next generation sequencing and copy number analyses was performed 1462 patients with Her2-non overexpressing metastatic breast cancer included in SAFIR02 Breast trial. 238 of these patients were randomized in two trials between a targeted therapy matched to genomic alteration and a maintenance chemotherapy. The trial shows that targeted therapies matched to genomics improves progression free survival (PFS) when genomic alterations are classified level I/II according to ESMO Scale for Clinical ... (Show More)

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
EGAD00010002239
Genomics to select patients with metastatic breast cancer for targeted therapy (microarray_cytoscan)
Cytoscan 749

Who archives the data?

There are no publications available