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Application of Hi-C sequencing to detect structural variants in B-cell acute lymphoblastic leukemia

Large structural variants are easily detected by Hi-C sequencing as strong, distant signals on a Hi-C contact map. Translocations are frequently evident in B-ALL and accurate identification of these translocations can guide clinical treatment options. Here were apply shallow Hi-C sequencing as an unbiased, cost-effective approach to identify translocations among B-ALL patients.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001008125 NextSeq 500 5
Publications Citations
Hi-C detects genomic structural variants in peripheral blood of pediatric leukemia patients.
Cold Spring Harb Mol Case Stud 8: 2022 a006157
5