A microRNA-signature that correlates with cognition and is a target against cognitive decline

Study ID Alternative Stable ID Type
EGAS00001005627 Other

Study Description

While some individuals age without pathological memory impairments, others develop age-associated cognitive diseases. Since changes in cognitive function develop slowly over time in these patients, they are often diagnosed at an advanced stage of molecular pathology, a time point when causative treatments fail. Thus, there is great need for the identification of inexpensive and minimal invasive approaches that could be used for screening with the aim to to identify individuals at risk for cognitive decline that can then undergo further diagnostics and eventually stratified therapies. In this study we use an integrative approach combining the analysis of human data and mechanistic studies in model systems to identify a circulating 3-microRNA signature that reflect key processes linked to neural homeostasis and informs about cognitive status. We furthermore provide evidence that expression changes of this signature represent multiple mechanisms de-regulated in the aging and diseased brain and are a suitable target for RNA therapeutics.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
smallRNA sequencing from healthy individuals and MCI patients, along with phenotypic information.
Illumina HiSeq 2000 145

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