Variation and transmission of the human gut microbiota across generations - 16S data

Study ID Alternative Stable ID Type
EGAS00001005651 Other

Study Description

Although composition and functional potential of the human gut microbiota evolve over lifespan, kinship has been identified as a key covariate of microbial community diversification. To date, sharing of microbiota features within families has however mostly been assessed between parents and their direct offspring. Here, we investigate potential transmission and persistence of familial microbiome patterns and microbial genotypes in a family cohort (N=102) spanning three to five generations over the same female bloodline. We observe microbiome community composition to be associated with kinship, with seven (low-abundant) genera displaying familial distribution patterns. While kinship and current cohabitation emerged as closely entangled variables, our explorative analyses of microbial genotype distribution and transmission estimates point at the latter as a key covariate of strain dissemination. Highest potential transmission rates are estimated between sisters and mother-daughter pairs, decreasing with increasing daughter’s age, and being higher among cohabiting pairs than those ... (Show More)

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
Variation and transmission of the human gut microbiota across generations - 16S sequencing data
Illumina HiSeq 2500 102

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