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Disturbed trophoblast transition links early fetal to maternal syndrome progression in pre-eclampsia

Type: Transcriptome Analysis
Archive: European Genome-phenome Archive (EGA)

1 Dataset 2 Publications

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Dataset ID	Description	Technology	Samples
EGAD00001008273	Hypertensive disorders in pregnancy, of which the multisystem syndrome pre-eclampsia is the most severe, leading to preterm delivery, maternal mortality, and life-long complications. To elucidate early disease dynamics, we present the first spatio-temporal study comparing single-nuclei transcriptomes of human preterm pre-eclamptic placentae and healthy controls, contextualizing this in a comprehensive study including early and late gestational placentae. This study includes early placentae samples from the fetal part (villi; n=10), maternal part (Decidua; n=3), late placentae samples from healthy pregnancies, villi (n=6), decidua (n=4), and late placentae samples from early-onset preeclamptic pregnancies, villi (n=5) and decidua (n=5).	Illumina HiSeq 4000	22

Publications	Citations
Cystatin 6 (CST6) and Legumain (LGMN) are potential mediators in the pathogenesis of preeclampsia. Botha SM, Bartho LA, Hartmann S, Cannon P, Nguyen A, Nguyen TV, Pritchard N, Dechend R, Nonn O, Tong S, Kaitu'u-Lino TJ. Sci Rep 15: 2025 12945	7
Syncytiotrophoblast differentiation defects drive ER stress and reprogram placental PSG1 glycosylation in preeclampsia. Harms C, Wang Y, Warren J, Baumeister J, Higel F, Antich C, Ferrer M, Hill JJ, Garcia MG, Gellhaus A, Than NG, Herse F, Verlohren S, Dveksler GS, Blois SM. Mol Biomed 7: 2026 235	0