MM samples for epigenomic translocation of H3K4me3 broad domains following super-enhancer hijacking
Chromosomal translocations are important drivers of haematological malignancies whereby proto-oncogenes are activated by juxtaposition with super-enhancers, often called enhancer hijacking. To examine this phenomenon we used ChipSeq based on a combination of six histone modifications as follows: H3K4me1, H3K4me3, H3K9me3, H3K27me3, H3K27Ac and H3K36me3. Samples are patient-derived xenografts generated by passaging primary patient CD138+ selected cells through the SCID-rab myeloma mouse model.
- Type: Other
- Archiver: European Genome-Phenome Archive (EGA)
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Epigenomic translocation of H3K4me3 broad domains over oncogenes following hijacking of super-enhancers.
Genome Res 32: 2022 1343-1354