Longitudinal profiling of circulating tumour DNA for tracking tumour dynamics in pancreatic cancer

Study ID Alternative Stable ID Type
EGAS00001005981 Other

Study Description

The utility of circulating tumour DNA (ctDNA) for longitudinal tumour monitoring in pancreatic ductal adenocarcinoma (PDAC) has not been explored beyond mutations in the KRAS proto-oncogene. We aim to characterise and track patient-specific somatic ctDNA variants, to assess longitudinal changes in disease burden and explore the landscape of actionable alterations.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
Whole genome sequencing from two resectable patients with pancreatic cancer for both normal and tumour tissue samples; whole exome sequencing from the two resectable patients and five unresectable patients of peripheral blood mononuclear cells and blood plasma (1-5 time points per patient), and whole exome sequencing of plasma samples from three chronic pancreatitis patients.
Illumina HiSeq 4000,Illumina NovaSeq 6000 34

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