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Host genotyping data from Dutch adult bacterial meningitis patients and linked bacterial genome sequences

Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a role in invasive pneumococcal disease, though to what extent is unknown. This study includes 1146 samples of host genotyping data (genotyped and imputed) from Illumina Omni arrays. Samples were collected from adults (>16 yrs) patients with CSF confirmed bacterial meningitis in the Netherlands between 2006 and 2015. Metadata includes patient outcome, species of bacteria, and for 467 samples a link to an ENA run with the associated bacterial genome (S. pneumoniae only).

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00010002327 Illumina Human Omni1-Quad beadchip. 1149
EGAD00010002328 Illumina Human Omni1-Quad beadchip. 1149
Publications Citations
Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis.
Nat Commun 10: 2019 2176