Study

Profiling of 27 type 2 diabetes GWAS loci using next-generation (NG) capture C in a human beta-cell model

Study ID Alternative Stable ID Type
EGAS00001006105 Other

Study Description

Most type 2 diabetes association signals are due to variants that impact gene regulation but identifying the genes they impact is challenging. We generated interaction profiles at 27 T2D GWAS loci using next-generation (NG) capture C in a human beta-cell model ( EndoC-betaH1) and contrasted our maps with public Hi-C/promoter capture Hi-C maps in EndoC-betaH1 cells or human islets.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
EGAD00001008655
Most type 2 diabetes association signals are due to variants that impact gene regulation but identifying the genes they impact is challenging. We generated interaction profiles at 27 T2D GWAS loci using next-generation (NG) capture C (6 replicates) in the human beta-cell model, EndoC-betaH1, along with chromatin accessibility profiling using ATAC-Seq (9 replicates).
NextSeq 500 15

Who archives the data?

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