Profiling of 27 type 2 diabetes GWAS loci using next-generation (NG) capture C in a human beta-cell model

Most type 2 diabetes association signals are due to variants that impact gene regulation but identifying the genes they impact is challenging. We generated interaction profiles at 27 T2D GWAS loci using next-generation (NG) capture C in a human beta-cell model ( EndoC-betaH1) and contrasted our maps with public Hi-C/promoter capture Hi-C maps in EndoC-betaH1 cells or human islets.

Type: Other
Archiver: EGA European Genome-Phenome Archive

2 Datasets

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Dataset ID	Description	Technology	Samples
EGAD00001008655	Most type 2 diabetes association signals are due to variants that impact gene regulation but identifying the genes they impact is challenging. We generated interaction profiles at 27 T2D GWAS loci using next-generation (NG) capture C (6 replicates) in the human beta-cell model, EndoC-betaH1, along with chromatin accessibility profiling using ATAC-Seq (9 replicates).	NextSeq 500	15
EGAD00001011374	HNF1A haploinsufficiency causes decreased insulin expression, dysregulation of pancreatic progenitor signature genes and affects chromatin accessibility	Illumina NovaSeq 6000 NextSeq 500	1