Mapping genetic effects on cell type-specific chromatin accessibility using single nucleus ATAC-seq

Gene regulation is highly cell type-specific and understanding the function of non-coding genetic variants associated with complex traits requires molecular phenotyping at cell type resolution. In this study we performed single nucleus ATAC-seq (snATAC-seq) and genotyping in peripheral blood mononuclear cells from 13 individuals. We mapped chromatin accessibility QTLs (caQTLs) in each immune cell type and sub-type in a subset of 10 samples of European genetic ancestry.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00010002308	Combined genotyping files from 13 PBMC samples	illumina Infinium Omni2.5-8	13

Publications	Citations
Mapping genetic effects on cell type-specific chromatin accessibility and annotating complex immune trait variants using single nucleus ATAC-seq in peripheral blood. Benaglio P, Newsome J, Han JY, Chiou J, Aylward A, Corban S, Miller M, Okino ML, Kaur J, Preissl S, Gorkin DU, Gaulton KJ. PLoS Genet 19: 2023 e1010759	16