Mapping genetic effects on cell type-specific chromatin accessibility using single nucleus ATAC-seq

Study ID Alternative Stable ID Type
EGAS00001006184 Other

Study Description

Gene regulation is highly cell type-specific and understanding the function of non-coding genetic variants associated with complex traits requires molecular phenotyping at cell type resolution. In this study we performed single nucleus ATAC-seq (snATAC-seq) and genotyping in peripheral blood mononuclear cells from 13 individuals. We mapped chromatin accessibility QTLs (caQTLs) in each immune cell type and sub-type in a subset of 10 samples of European genetic ancestry.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
Combined genotyping files from 13 PBMC samples
illumina Infinium Omni2.5-8 13

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