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Extensive patient-to-patient single nuclei transcriptome heterogeneity in pheochromocytomas and paragangliomas

Pheochromocytomas (PC) and paragangliomas (PG) are rare neuroendocrine tumors of varied genetic makeup, associated with high cardiovascular morbidity and a variable risk of malignancy. We focused on PCPG tumors with germline SDHB and RET mutations, representing distinct prognostic groups with worse or better prognoses, respectively. We applied single-nuclei RNA sequencing (snRNA-seq) on tissue samples from 11 patients.

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Dataset ID Description Technology Samples
EGAD00001008739 NextSeq 500 1
Publications Citations
Extensive patient-to-patient single nucleus transcriptome heterogeneity in pheochromocytomas and paragangliomas.
Front Oncol 12: 2022 965168