Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression
Genome-wide studies have uncovered multiple independent signals at the RREB1 locus associated with altered type 2 diabetes risk and related glycemic traits. However, little is known about the function of the zinc finger transcription factor RREB1 in glucose homeostasis or how changes in its expression and/or function influences diabetes risk.
- Type: Other
- Archiver: EGA European Genome-Phenome Archive
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Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression.
Diabetologia 66: 2023 674-694