Placebo-only arm transcriptomic analysis of the phase 3 PROTECT clinical trial

Study ID Alternative Stable ID Type
EGAS00001006344 Other

Study Description

It is poorly understood how the tumor immune microenvironment influences disease recurrence in localized clear cell renal cell carcinoma (ccRCC). Here we perform whole-transcriptomic profiling of 236 tumors from patients assigned to the placebo-only arm of a randomized, adjuvant clinical trial for high-risk localized ccRCC. Unbiased pathway analysis identifies myeloid-derived interleukin-6 (IL-6) as a key mediator. Furthermore, a novel myeloid gene signature strongly correlates with disease recurrence and overall survival on uni- and multivariate analysis and is linked to TP53 inactivation across multiple datasets.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
high-risk localized ccRCC
Affymetrix HTA 2.0 236

Who archives the data?

There are no publications available