Clonal dominance defines metastatic dissemination in pancreatic cancer

Study ID Alternative Stable ID Type
EGAS00001006358 Other

Study Description

Using patient-derived cells from a pancreatic ductal adenocarcinoma, we created orthotopic clonal replica tumors to trace in an unbiased fashion clonal lineage dynamics of unperturbed tumor expansion and dissemination over time. The model revealed the complex multifaced nature of tumor clonal expansion and uncovered brisk changes in fitness that lead to a continuous reshuffling of tumor clonal architecture and alternating clonal dominance as a distinct feature of cancer growth. Paired analysis of clonal lineages in primary and secondary sites revealed fitness in the primary tumor as a major contributor to dissemination, although other clonal intrinsic and extrinsic factors may contribute to metastatic process. Molecular characterization of lineages with differential metastatic potential identified actionable strategy to suppress dissemination at the subclonal level.

Study Datasets 4 datasets.

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Dataset ID Description Technology Samples
Illumina HiSeq 2500 6
Illumina HiSeq 2500 6
single cell RNA-seq
unspecified 6
single cell DNA sequencing
unspecified 6

Who archives the data?

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