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Molecular_QTLs_of_Human_umbilical_vein_endothelial_cellsHUVECs

We aim to characterise the range of phenotypic variation in gene expression, epigenetic regulation and intermediate functional phenotypes and its underlying genetic determinants in primary Human umbilical vein endothelial cells (HUVECs) samples We will measure gene expression by RNA sequencing (RNA-seq), genome functionality by ATAC-sequencing (ATAC-seq, to determine which regions are in an open chromatin state) and by determining H3 lysine 27acetylation (H3K27ac), a marker of active transcriptional enhancers, localisation genome wide by chromatin immunoprecipitation coupled with sequencing (ChIP-seq).

Type: Gene Regulation Study
Archive: European Genome-phenome Archive (EGA)

1 Dataset

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Dataset ID	Description	Technology	Samples
EGAD00001016140	We aim to characterise the range of phenotypic variation in gene expression, epigenetic regulation and intermediate functional phenotypes and its underlying genetic determinants in primary Human umbilical vein endothelial cells (HUVECs) samples We will measure gene expression by RNA sequencing (RNA-seq), genome functionality by ATAC-sequencing (ATAC-seq, to determine which regions are in an open chromatin state) and by determining H3 lysine 27acetylation (H3K27ac), a marker of active transcriptional enhancers, localisation genome wide by chromatin immunoprecipitation coupled with sequencing (ChIP-seq).	Illumina HiSeq 2500 Illumina MiSeq Illumina NovaSeq 6000	426

Molecular_QTLs_of_Human_umbilical_vein_endothelial_cells__HUVECs__

Molecular_QTLs_of_Human_umbilical_vein_endothelial_cellsHUVECs