Blina Tumour project
|Study ID||Alternative Stable ID||Type|
|EGAS00001006486||Whole Genome Sequencing|
The aim of this study is to reconstruct the embryology of childhood tumours.
Study Datasets 1 dataset.
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
Children with ALL treated with anti-CD19 therapy occasionally develop a phenotypically distinct AML. However, the precise clonal origin of such class switch leukemias remains unresolved. Here, we reconstructed the evolution of leukemia in a child with primary ALL, two ALL relapses and AML after treatment with anti-CD19 CAR-T and blinatumomab through whole-genome sequencing. The phylogeny revealed that the AML was a monoclonal outgrowth descending from the initial ALL and harbored biallelic loss ... (Show More)
|Illumina NovaSeq 6000||8|