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SPECIAL: Dissecting the melanoma ecosystem one cell at the time during immunotherapy

The aim of this study was to identify potential biomarkers of response to immunotherapy (anti-PD1-based) as well as gain understanding of the biological mechanism of therapy resistance (either intrinsic or acquired) in melanoma patients. Single cell RNA sequencing was performed from pre- and on-treatment (2-3 weeks after immunotherapy) metastatic biopsies from stage III and IV melanoma patients.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001009291 unspecified 46
EGAD00001010921 unspecified 6
Publications Citations
CD4<sup>+</sup> T cell-induced inflammatory cell death controls immune-evasive tumours.
Nature 618: 2023 1033-1040
186
The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity.
Cancer Cell 41: 2023 1207-1221.e12
46
STmut: a framework for visualizing somatic alterations in spatial transcriptomics data of cancer.
Genome Biol 24: 2023 273
14
ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma.
Cell Rep 43: 2024 114406
9
Single-Cell Transcriptomic Landscape Deciphers Intratumoral Heterogeneity and Subtypes of Acral and Mucosal Melanomas.
Clin Cancer Res 31: 2025 2495-2514
2
MCSP&lt;sup&gt;+&lt;/sup&gt; metastasis founder cells activate immunosuppression early in human melanoma metastatic colonization.
Nat Cancer 6: 2025 1017-1034
1
Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype.
Cancer Discov 15: 2025 1819-1834
4
A comparative transcriptomic analysis at single-cell resolution reveals acral melanoma features distinct from cutaneous melanoma.
Chin J Cancer Res 37: 2025 558-574
1
Single-cell mapping of alternative splicing linked to checkpoint immunotherapy response.
Nucleic Acids Res 53: 2025 gkaf1171
0