Single-cell transcriptome landscape of developing fetal gonads defines somatic cell lineage specification in humans

We present the comprehensive transcriptional dynamics of cell types populating the male and female developing gonads at a single-cell level. We recovered the gene expression programs of around 128,000 single cells derived from 17 fetal testes and 16 fetal ovaries from 5 to 12 postconceptional weeks. The resulting dataset provides an unprecedented overview of this key period in sex determination and gonadal development.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001009811	Single-cell RNA-seq dataset recovering the gene expression programs of around 128,000 single cells derived from 17 fetal testes and 16 fetal ovaries from 5 to 12 postconceptional weeks.	Illumina HiSeq 4000	33

Publications	Citations
How relevant is the mouse model for understanding human sex determination? Brito F, Mayère C, Lardenois A, Regard V, Czukiewska S, Djari C, Sararols P, Neirijnck Y, Kühne F, Mazaud-Guittot S, Lopes SMCS, Chalmel F, Rolland AD, Nef S. Int J Biol Sci 21: 2025 6599-6615	0