Study
Gene copy number variation in pediatric mental illness in a general population
| Study ID | Alternative Stable ID | Type |
|---|---|---|
| EGAS00001006659 | Other |
Study Description
We assessed the relationship of gene copy number variation (CNV) in mental health/neurodevelopmental traits and diagnoses, physical health, and cognitive biomarkers in a community sample of 7,100 unrelated European, and East Asian children and youth (Spit for Science). Diagnoses of mental health disorders were found in 17.5% of participants and 27.6% scored in the highest 10% on either or both ADHD and OCD trait measures. Clinically relevant CNVs were present in 3.9% of participants and were associated with elevated scores on a continuous measure of ADHD (p=5.0×10-3), on a cognitive biomarker of mental health (response inhibition (p=1.0×10-2)), and on prevalence of mental disorders (p=1.9×10-6, odds ratio: 3.09). With a rise of mental illness, our data establishes a baseline for delineating genetic contributors in paediatric-onset conditions.
Study Datasets 2 datasets.
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
| Dataset ID | Description | Technology | Samples |
|---|---|---|---|
| EGAD00010002374 |
DNA was extracted from saliva samples and genotyping was performed on Illumina Infinium Global Screening Array.
|
Global Screening Array | 1880 |
| EGAD00010002375 |
DNA was extracted from saliva samples and genotyping was performed on Illumina Infinium HumanCoreExome beadchips.
|
HumanCoreExome | 5220 |
Who archives the data?
