Gene copy number variation in pediatric mental illness in a general population

We assessed the relationship of gene copy number variation (CNV) in mental health/neurodevelopmental traits and diagnoses, physical health, and cognitive biomarkers in a community sample of 7,100 unrelated European, and East Asian children and youth (Spit for Science). Diagnoses of mental health disorders were found in 17.5% of participants and 27.6% scored in the highest 10% on either or both ADHD and OCD trait measures. Clinically relevant CNVs were present in 3.9% of participants and were associated with elevated scores on a continuous measure of ADHD (p=5.0×10-3), on a cognitive biomarker of mental health (response inhibition (p=1.0×10-2)), and on prevalence of mental disorders (p=1.9×10-6, odds ratio: 3.09). With a rise of mental illness, our data establishes a baseline for delineating genetic contributors in paediatric-onset conditions.

Type: Other
Archiver: EGA European Genome-Phenome Archive

2 Datasets

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Dataset ID	Description	Technology	Samples
EGAD00010002374	DNA was extracted from saliva samples and genotyping was performed on Illumina Infinium Global Screening Array.	Global Screening Array	1880
EGAD00010002375	DNA was extracted from saliva samples and genotyping was performed on Illumina Infinium HumanCoreExome beadchips.	HumanCoreExome	3295