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Multifocal cohort analysis unveils cell types associated with regional lymph node seeding in prostate cancer

The aim of this project was to assess the effect of intratumor heterogeneity on pathological and molecular markers in locally advanced prostate cancer. We demonstrate how primary lesions with a higher metastatic potential more closely resemble the state in the metastatic lymph nodes, for some biological signatures. Finally, we developed a statistical procedure to identify the most likely seeding lesion and introduced a statistical testing procedure to leverage the intratumor heterogeneity to identify signatures that characterize the seeding lesion.

Type: RNASeq
Archiver: European Genome-phenome Archive (EGA)

2 Datasets

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000002380	Fastq files from RNA sequencing and BAM files from tNGS of normal and tumor samples from 17 patients from the locally advanced prostate cancer cohort.	Illumina NovaSeq 6000 unspecified	164
EGAD50000002381	Fastq files from RNA sequencing of normal and tumor samples from 16 patients from the de novo metastatic prostate cancer cohort.	Illumina NovaSeq 6000	46