A single-cell transcriptional gradient in human cutaneous memory T cells restricts Th17/Tc17 identity
We identified a gradated transcriptional program of coordinately regulated inflammation-suppressive genes in psoriatic resident memory T cells. This dataset includes bulk RNA-seq for CRISPR-based deactivation of two core components of this inflammation-suppressive program, ZFP36L2 and ZFP36, in human PBMCs. It also includes scRNA-seq of cutaneous immune cells from psoriasis patients before and during therapeutic IL-23 blockade.
- Type: Other
- Archiver: European Genome-Phenome Archive (EGA)
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
|Illumina HiSeq 4000 Illumina NovaSeq 6000
Isolation of human cutaneous immune cells for single-cell RNA sequencing.
STAR Protoc 4: 2023 102239