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A single-cell transcriptional gradient in human cutaneous memory T cells restricts Th17/Tc17 identity

We identified a gradated transcriptional program of coordinately regulated inflammation-suppressive genes in psoriatic resident memory T cells. This dataset includes bulk RNA-seq for CRISPR-based deactivation of two core components of this inflammation-suppressive program, ZFP36L2 and ZFP36, in human PBMCs. It also includes scRNA-seq of cutaneous immune cells from psoriasis patients before and during therapeutic IL-23 blockade.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001009677 Illumina HiSeq 4000 Illumina NovaSeq 6000 17
Publications Citations
Isolation of human cutaneous immune cells for single-cell RNA sequencing.
STAR Protoc 4: 2023 102239