Molecular evolution of classic Hodgkin lymphoma revealed through whole genome sequencing of Hodgkin and Reed Sternberg cells

Study ID Alternative Stable ID Type
EGAS00001006884 Other

Study Description

Here we leveraged whole genome structural variant copy number analysis to report the first whole genome sequencing landscape of HRS cells and reconstruct the chronology and likely etiology of pathogenic events prior to the clinical diagnosis of cHL.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
Whole genome sequencing of 17 paired tumor-normal Hodgkin Lymphoma whole genomes. Bulk tumor (-T) and flow-sorted Reed Sternberg cell (-HRS) samples. Approximately 30x wgs normal depth, 40-50x wgs depth tumor samples.
Illumina NovaSeq 6000 53

Who archives the data?

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