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A single cell view on host immune transcriptional response to in vivo BCG-induced trained immunity

Type: Transcriptome Analysis
Archiver: European Genome-phenome Archive (EGA)

1 Dataset 5 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001010055	We have paired 39 individuals in 4 conditions: T0_RPMI (baseline, before BCG and without LPS); T0_LPS (before BCG and with LPS); T3m_RPMI (3 months after BCG, without LPS); T3m_LPS (3 months after BCG, with LPS).	Illumina NovaSeq 6000	32

Publications	Citations
A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity. Li W, Moorlag SJCFM, Koeken VACM, Röring RJ, de Bree LCJ, Mourits VP, Gupta MK, Zhang B, Fu J, Zhang Z, Grondman I, van Meijgaarden KE, Zhou L, Alaswad A, Joosten LAB, van Crevel R, Xu CJ, Netea MG, Li Y. Cell Rep 42: 2023 112487	39
BCG vaccination-induced acquired control of mycobacterial growth differs from growth control preexisting to BCG vaccination. van Meijgaarden KE, Li W, Moorlag SJCFM, Koeken VACM, Koenen HJPM, Joosten LAB, Vyakarnam A, Ahmed A, Rakshit S, Adiga V, Ottenhoff THM, Li Y, Netea MG, Joosten SA. Nat Commun 15: 2024 114	9
Single-cell immune aging clocks reveal inter-individual heterogeneity during infection and vaccination. Li W, Zhang Z, Kumar S, Botey-Bataller J, Zoodsma M, Ehsani A, Zhan Q, Alaswad A, Zhou L, Grondman I, Koeken V, Yang J, Wang G, Volland S, Crişan TO, Joosten LAB, Illig T, Xu CJ, Netea MG, Li Y. Nat Aging 5: 2025 607-621	13
Unveiling genetic signatures of immune response in immune-related diseases through single-cell eQTL analysis across diverse conditions. Zhang Z, Li W, Zhan Q, Aillaud M, Botey-Bataller J, Zoodsma M, Ter Horst R, Joosten LAB, Bock C, Schulte LN, Xu CJ, Netea MG, Bonder MJ, Li Y. Nat Commun 16: 2025 7134	2
Multi-Omics Analysis Reveals Sex-Specific Signatures for BCG Vaccine Efficacy. Zhan Q, Zhou L, Fu J, Jiang X, Liu X, Li W, Moorlag SJCFM, Koeken VACM, de Bree LCJ, Mourits VP, Joosten LAB, Li Y, Netea MG, Xu CJ. Eur J Immunol 56: 2026 e70144	0