Study
Integrated single cell analysis in transformed follicular lymphoma
| Study ID | Alternative Stable ID | Type |
|---|---|---|
| EGAS00001007023 | Other |
Study Description
Histological transformation of follicular lymphoma to aggressive form occurs 2-3% per year with poor outcome. Divergent evolution and an altered tumour-microenvironment (TME) have been implicated during transformation. However, phenotypic consequences of this evolution and its implication in TME remain unknown. To address this, we performed single cell whole genome and whole transcriptome sequencing of paired pre/post transformation patient samples. We further performed scWTS of additional samples from patients without transformation. Our analysis revealed evolutionary dynamics of transformation at unprecedented resolution. Integration of scWGS and scWTS identified pathways upregulated during evolution. scWTS analysis revealed a shifting TME landscape, with an exhausted signature emerging during transformation. Using multi-color immunofluorescence we transferred these findings to a TME-based transformation biomarker, subsequently validated in independent pretreatment cohorts. Taken together, our results provide a comprehensive view of the combined genomic and phenotypic evolution of ... (Show More)
Study Datasets 45 datasets.
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
| Dataset ID | Description | Technology | Samples |
|---|---|---|---|
| EGAD00001010204 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0167_003 for Follicular lymphoma patient sample TFRI_Cont_2
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010205 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0168_003 for Follicular lymphoma patient sample TFRI_Cont_3
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010206 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0169_003 for Follicular lymphoma patient sample TFRI_Cont_4
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010207 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0170_003 for Follicular lymphoma patient sample TFRI_Cont_5
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010208 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0171_003A for Follicular lymphoma patient sample TFRI_Cont_6
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010209 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0178_003A for Follicular lymphoma patient sample TFRI_Cont_8
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010210 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0183_003A for Follicular lymphoma patient sample TFRI_Cont_9
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010211 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0187_003A for Follicular lymphoma patient sample TFRI_Cont_10
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010212 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0188_003A for Follicular lymphoma patient sample TFRI_Cont_11
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010213 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0197_003A for Follicular lymphoma patient sample TFRI_Cont_12
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010214 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0198_003A for Follicular lymphoma patient sample TFRI_Cont_13
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010215 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0167_001 for Follicular lymphoma patient sample TFRIPAIR2_FL
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010216 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0168_001 for Follicular lymphoma patient sample TFRIPAIR3_FL
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010217 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0169_001 for Follicular lymphoma patient sample TFRIPAIR4_FL
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010218 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0170_001A for Follicular lymphoma patient sample TFRIPAIR5_FL
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010219 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0171_001A for Follicular lymphoma patient sample TFRI_Pair_6_FL
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010220 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0178_001A for Follicular lymphoma patient sample TFRIPAIR8_FL
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010221 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0183_001A for Follicular lymphoma patient sample TFRIPAIR9_FL
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010222 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0187_001A for Follicular lymphoma patient sample TFRIPAIR10_FL
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010223 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0188_001A for Follicular lymphoma patient sample TFRIPAIR11_FL
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010224 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0197_001A for Follicular lymphoma patient sample TFRIPAIR12_FL
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010225 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0198_001A for Follicular lymphoma patient sample TFRI_Pair_13_FL
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010226 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0167_002 for Diffuse large B-cell lymphoma patient sample TFRIPAIR2_DLBCL
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010227 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0168_002 for Diffuse large B-cell lymphoma patient sample TFRIPAIR3_DLBCL
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010228 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0169_002 for Diffuse large B-cell lymphoma patient sample TFRIPAIR4_DLBCL
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010229 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0170_002A for Diffuse large B-cell lymphoma patient sample TFRIPAIR5_DLBCL
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010230 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0171_002A for Diffuse large B-cell lymphoma patient sample TFRI_Pair_6_DLBCL
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010231 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0178_002A for Diffuse large B-cell lymphoma patient sample TFRIPAIR8_DLBCL
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010232 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0183_002A for Diffuse large B-cell lymphoma patient sample TFRI_Pair_9_DLBCL
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010234 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0188_002A for Diffuse large B-cell lymphoma patient sample TFRIPAIR11_DLBCL
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010235 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0197_002A for Diffuse large B-cell lymphoma patient sample TFRIPAIR12_DLBCL_rel
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010236 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0198_002A for Diffuse large B-cell lymphoma patient sample TFRI_Pair_13_DLBCL
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010237 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0198_004A for Lymph node patient sample RLN_02_5Prime
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010238 |
10x Single Cell Gene Expression library SCRNA10X_CS_CHIP0198_005A for Lymph node patient sample RLN_03_5Prime
|
Illumina HiSeq 2500 | 1 |
| EGAD00001010239 |
DLP+ Single Cell Genomic Library 98211 for Diffuse large B-cell lymphoma patient sample TFRIPAIR11_DLBCL
|
HiSeq X Ten | 1 |
| EGAD00001010240 |
DLP+ Single Cell Genomic Library A98180 for Diffuse large B-cell lymphoma patient sample TFRI_Pair_13_DLBCL
|
HiSeq X Ten | 1 |
| EGAD00001010241 |
DLP+ Single Cell Genomic Library A98193 for Follicular lymphoma patient sample TFRI_Pair_6_FL
|
HiSeq X Ten | 1 |
| EGAD00001010242 |
DLP+ Single Cell Genomic Library A98203 for Diffuse large B-cell lymphoma patient sample TFRIPAIR8_DLBCL
|
HiSeq X Ten | 1 |
| EGAD00001010243 |
DLP+ Single Cell Genomic Library A98205 for Follicular lymphoma patient sample TFRIPAIR9_FL
|
HiSeq X Ten | 1 |
| EGAD00001010244 |
DLP+ Single Cell Genomic Library A98208 for Diffuse large B-cell lymphoma patient sample TFRIPAIR10_DLBCL
|
HiSeq X Ten | 1 |
| EGAD00001010245 |
DLP+ Single Cell Genomic Library A98221A for Follicular lymphoma patient sample TFRIPAIR5_FL
|
HiSeq X Ten | 1 |
| EGAD00001010246 |
DLP+ Single Cell Genomic Library A98225 for Diffuse large B-cell lymphoma patient sample TFRIPAIR12_DLBCL_rel
|
HiSeq X Ten | 1 |
| EGAD00001010247 |
DLP+ Single Cell Genomic Library A98288 for Follicular lymphoma patient sample TFRIPAIR2_FL
|
HiSeq X Ten | 1 |
| EGAD00001010248 |
DLP+ Single Cell Genomic Library A98297 for Follicular lymphoma patient sample TFRIPAIR3_FL
|
HiSeq X Ten | 1 |
| EGAD00001010249 |
DLP+ Single Cell Genomic Library A98167 for Diffuse large B-cell lymphoma patient sample TFRIPAIR4_DLBCL
|
HiSeq X Ten | 1 |
Who archives the data?
