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Genetic Determinants of Transcriptional Variation in Primary Human Monocytes Across Multiple Contexts

Monocytes undergo global gene expression changes upon stimulation, thus a significant proportion of eQTL are specific to activation state. Here we systematically explore determinants of gene and transcript expression in monocytes from 185 individuals in the untreated state and post-exposure to IFN╬│ or lipopolysaccharide (LPS).

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Dataset ID Description Technology Samples
EGAD00001010176 Illumina HiSeq 4000 611
Publications Citations
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.
Nature 617: 2023 764-768
19