Human liver NPCs single cell project

Study ID Alternative Stable ID Type
EGAS00001007194 Other

Study Description

Independent of their inflammatory phenotype, macrophages are key orchestrators of hepatic metabolism. Non-alcoholic fatty liver disease (NAFLD) often occurs in obese individuals and is among the most common causes of cirrhosis, the terminal chronic liver disease that may necessitate liver transplantation. While multiple populations of macrophages have been described in the human liver, their function and turnover in obese patients at high risk of developing NAFLD and cirrhosis is currently unknown. Herein we identified a specific human population of resident liver myeloid cells that protects against the metabolic impairment associated with obesity. By studying the turnover of liver myeloid cells in individuals undergoing liver transplantation using markers of donor-recipient mismatch, we made the novel discovery that liver myeloid cell turnover differs between humans and mice. Using single cell techniques and flow cytometry we determined that the proportion of the protective resident liver myeloid cells, denoted liver myeloid cells 2 (LM2), decreases during obesity. Functional ... (Show More)

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
Smart-seq2 single-cell RNA-seq of human liver non-parenchymal cells from lean and obese individuals
Illumina HiSeq 3000 1262

Who archives the data?

There are no publications available