Differentiation-associated ISG expression of NK cells in chronic viral hepatitis

Little is known about the effects of ISGs on NK cell responses in chronic viral hepatitis. Here, we determined the expression, regulation and function of ISGs in NK cells with respect to phenotype and function, we performed high-throughput single cell RNA sequencing of circulating CD3-CD56+ NK cells from healthy donors (HD) and patients with chronic HBV or HCV infections.

Type: Transcriptome Analysis
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

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Dataset ID	Description	Technology	Samples
EGAD50000001623	Little is known about the effects of ISGs on NK cell responses in chronic viral hepatitis. Here, we determined the expression, regulation and function of ISGs in NK cells with respect to phenotype and function, we performed high-throughput single cell RNA sequencing of circulating CD3-CD56+ NK cells from healthy donors (HD) and patients with chronic HBV or HCV infections.	NextSeq 550	16

Publications	Citations
Differentiation-associated ISG expression of NK cells in chronic viral infection. Keller F, Chua RL, Trefzer T, Jechow K, Bauersfeld L, Beier F, Sagar, Sogukpinar Ö, Rusignuolo G, Rizzi M, Eils R, Pichlmair A, Binder M, Bengsch B, Neumann-Haefelin C, Lohmann V, Boettler T, Conrad C, Thimme R, Hofmann M. iScience 28: 2025 113216	0