Tumor-associated neutrophil 1 precursors impair homologous DNA repair and promote sensitivity to PARP-inhibition

Tumor evolution is one of the major mechanisms responsible for acquiring therapy resistant and more aggressive cancer clones. Whether the tumor microenvironment through immune-mediated mechanisms might promote the development of more aggressive cancer types is crucial for the identification of additional therapeutical opportunities. Here, we identify a subset of tumor-associated neutrophils, defined as tumor-associated neutrophil precursors (PreNeu). These PreNeu are enriched in highly proliferative hormone-dependent breast cancers and impair DNA repair capacity

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

1 Publication

Publications	Citations
Tumor-associated neutrophil precursors impair homologous DNA repair and promote sensitivity to PARP inhibition. Mukherjee S, Garda C, Boffa L, Elia AR, Massara M, Balia MT, Brina D, Mosole S, Campagnari A, Cassanmagnago GA, Rinaldi A, Lazzaroni G, Jarrossay D, Morone D, Ceppi I, De Sillo R, Giacomini I, Craparotta I, Di Rito L, Barry S, Laczko E, Streb S, Meani F, Di Lascio S, Hynes N, Lugli E, Puccio S, Sammut SJ, Perriard U, Harder Y, Rossi L, Gasparri ML, Bolis M, Cejka P, Calcinotto A. Nat Commun 16: 2025 6999	1

Publications

Citations

Tumor-associated neutrophil precursors impair homologous DNA repair and promote sensitivity to PARP inhibition.
Mukherjee S, Garda C, Boffa L, Elia AR, Massara M, Balia MT, Brina D, Mosole S, Campagnari A, Cassanmagnago GA, Rinaldi A, Lazzaroni G, Jarrossay D, Morone D, Ceppi I, De Sillo R, Giacomini I, Craparotta I, Di Rito L, Barry S, Laczko E, Streb S, Meani F, Di Lascio S, Hynes N, Lugli E, Puccio S, Sammut SJ, Perriard U, Harder Y, Rossi L, Gasparri ML, Bolis M, Cejka P, Calcinotto A. Nat Commun 16: 2025 6999