RNA-seq of CD34+ HSPCs from LRMDS patients

To profile transcriptional alterations of HSPCs in LR-MDS patients, 7AAD−CD45+Lin-CD235a−CD34+ cells were isolated from healthy donors and LR-MDS patients for RNA sequencing.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001015771	To profile transcriptional alterations of HSPCs in LR-MDS patients, 7AAD−CD45+Lin-CD235a−CD34+ cells were isolated from healthy donors and LR-MDS patients for RNA sequencing.	Illumina NovaSeq 6000	1

Publications	Citations
An inflammatory T-cell-stromal axis contributes to hematopoietic stem/progenitor cell failure and clonal evolution in human myelodysplastic syndrome. Chen L, Bian Y, Pronk E, van Dijk C, V D van Tienhoven T, Hoogenboezem RM, Bindels EM, Bosch D, Fazeli S, de Graaf AO, Westers TM, Kholmatov M, Zaugg JB, Moura PL, Hellström-Lindberg E, van de Loosdrecht AA, Jansen JH, Sanders MA, Raaijmakers MHGP. Nat Commun 16: 2025 10041	0

Publications

Citations

An inflammatory T-cell-stromal axis contributes to hematopoietic stem/progenitor cell failure and clonal evolution in human myelodysplastic syndrome.
Chen L, Bian Y, Pronk E, van Dijk C, V D van Tienhoven T, Hoogenboezem RM, Bindels EM, Bosch D, Fazeli S, de Graaf AO, Westers TM, Kholmatov M, Zaugg JB, Moura PL, Hellström-Lindberg E, van de Loosdrecht AA, Jansen JH, Sanders MA, Raaijmakers MHGP. Nat Commun 16: 2025 10041