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Multi-omic data of subjects of FUSION study

Finland-United States Investigation of NIDDM Genetics (FUSION) Study has sought to understand the genetic basis of type 2 diabetes (T2D) and diabetes-related traits including glucose, insulin, lipid levels, and obesity. We have performed extensive multi-omic characterization of the study subjects, including SNP array genotyping, whole genome/exome DNA sequencing of blood/tissue/iPSC cells generated from fibroblast, as well as RNAs. The study has provided crucial data for understanding molecular and cellular mechanisms of the disease-causing variants and their respective target genes. This set of data will be a valuable resource to the T2D community.

Type: Other
Archive: European Genome-phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000003057	This dataset contains bulk RNA-seq and DNA whole genome sequence (WGS) data from 12 induced pluripotent stem cell (iPSC) lines generated from FUSION donor fibroblasts. It also includes single nuclei ATAC-seq and RNA-seq data generated from the same POMC-like cells differentiated from iPSCs of eight additional FUSION donors and three unrelated individuals using multiome kit. The data were generated using Illumina sequencing.	Illumina NovaSeq 6000 Illumina NovaSeq X	106

Publications	Citations
Genetics of growth rate in induced pluripotent stem cells. Lee BN, Taylor HJ, Cipriani F, Narisu N, Robertson CC, Swift AJ, Sinha N, Yan T, Bonnycastle LL, Dale N, Butt A, Parsaud H, Semrau S, NYSCF Global Stem Cell Array Team, GENESiPS Consortium, iPSCORE Consortium, Knowles JW, Carcamo-Orive I, D'Antonio-Chronowska A, Frazer KA, Biesecker LG, Noggle S, Erdos MR, Paull D, Collins FS, Taylor DL. Stem Cell Reports 21: 2026 102928	0

Publications

Citations

Genetics of growth rate in induced pluripotent stem cells.
Lee BN, Taylor HJ, Cipriani F, Narisu N, Robertson CC, Swift AJ, Sinha N, Yan T, Bonnycastle LL, Dale N, Butt A, Parsaud H, Semrau S, NYSCF Global Stem Cell Array Team, GENESiPS Consortium, iPSCORE Consortium, Knowles JW, Carcamo-Orive I, D'Antonio-Chronowska A, Frazer KA, Biesecker LG, Noggle S, Erdos MR, Paull D, Collins FS, Taylor DL. Stem Cell Reports 21: 2026 102928