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Whole-blood RNA-seq in AtezoBev-treated HCC

This dataset contains RNA-sequencing BAM files generated from paired whole-blood RNA samples collected from patients with advanced hepatocellular carcinoma treated with first-line atezolizumab–bevacizumab immunotherapy. Samples were collected at baseline before the first infusion (T0) and immediately prior to the second infusion (T1). The dataset includes paired longitudinal samples from 24 patients, comprising 13 responders and 11 progressors. RNA sequencing was performed by Novogene using a GlobinClear-based non-directional mRNA library preparation strategy. These data support transcriptomic analyses of circulating immune activation, treatment response and resistance mechanisms under atezolizumab–bevacizumab therapy.

Type: Other
Archive: European Genome-phenome Archive (EGA)

1 Dataset

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Dataset ID	Description	Technology	Samples
EGAD00001016415	This dataset contains RNA-sequencing BAM files generated from paired whole-blood RNA samples collected from patients with advanced hepatocellular carcinoma treated with first-line atezolizumab–bevacizumab immunotherapy. Samples were collected at baseline before the first infusion (T0) and immediately prior to the second infusion (T1). The dataset includes paired longitudinal samples from 24 patients, comprising 13 responders and 11 progressors. RNA sequencing was performed by Novogene using a GlobinClear-based non-directional mRNA library preparation strategy. These data support transcriptomic analyses of circulating immune activation, treatment response and resistance mechanisms under atezolizumab–bevacizumab therapy.	Illumina NovaSeq X	48