Gene Expression Signature in Normal Mammary Gland from 83 Breast Cancer Patients Indicates Pre-tumorous Changes and Adverse Outcomes

This study assessed the transcriptomic profiles of 242 samples from 83 breast cancer patients with unfavorable outcomes, including paired uninvolved mammary gland samples collected at varying distances from primary lesions. As a reference, control samples from 53 mammoplasty individuals without cancer history were studied. A custom panel of 634 genes linked to breast cancer progression and metastasis was employed for expression profiling (targeted RNA sequencing), followed by whole-transcriptome (RNA sequencing) verification experiments and statistical analyses to discern molecular signatures and their clinical relevance.

Type: Transcriptome Sequencing
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000000017	Results of sequencing the targeted RNA-seq panel of breast cancer patients and controls. This dataset comprises of FASTQ files of 295 samples (both breast cancer patients and controls) and the results of mapping the FASTQ files to the reference human genome (hg38) available in a form of raw gene expression matrix.	HiSeq X Ten	295

Publications	Citations
Prelude to malignancy: A gene expression signature in normal mammary gland from breast cancer patients suggests pre-tumorous alterations and is associated with adverse outcomes. Andreou M, Jąkalski M, Duzowska K, Filipowicz N, Kostecka A, Davies H, Horbacz M, Ławrynowicz U, Chojnowska K, Bruhn-Olszewska B, Jankau J, Śrutek E, Las-Jankowska M, Bała D, Hoffman J, Hartman J, Pęksa R, Skokowski J, Jankowski M, Szylberg Ł, Maniewski M, Zegarski W, Nowikiewicz M, Nowikiewicz T, Dumanski JP, Mieczkowski J, Piotrowski A. Int J Cancer 155: 2024 1616-1628	0

Publications

Citations

Prelude to malignancy: A gene expression signature in normal mammary gland from breast cancer patients suggests pre-tumorous alterations and is associated with adverse outcomes.
Andreou M, Jąkalski M, Duzowska K, Filipowicz N, Kostecka A, Davies H, Horbacz M, Ławrynowicz U, Chojnowska K, Bruhn-Olszewska B, Jankau J, Śrutek E, Las-Jankowska M, Bała D, Hoffman J, Hartman J, Pęksa R, Skokowski J, Jankowski M, Szylberg Ł, Maniewski M, Zegarski W, Nowikiewicz M, Nowikiewicz T, Dumanski JP, Mieczkowski J, Piotrowski A. Int J Cancer 155: 2024 1616-1628