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Multi-omics characterisation of immune cells in Long Covid

We generated 10X Multiomics (paired RNA+ATAC) for Long Covid patients with up to 14 months follow-up.

Type: Transcriptome Sequencing
Archiver: European Genome-phenome Archive (EGA)

1 Dataset 2 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000000202	We generated 10X, droplet-based paired snRNAseq+snATACseq (Multiome) of patients suffering from Long Covid. In total, we included 31 patients. Single nuclei libraries are genetically multiplexed across donors, genotype files are available to enable demultiplexing. Phenotype sheets provide information of pools/donors as well as donor phenotype.	Illumina NovaSeq 6000	25

Publications	Citations
Single-cell immune aging clocks reveal inter-individual heterogeneity during infection and vaccination. Li W, Zhang Z, Kumar S, Botey-Bataller J, Zoodsma M, Ehsani A, Zhan Q, Alaswad A, Zhou L, Grondman I, Koeken V, Yang J, Wang G, Volland S, Crişan TO, Joosten LAB, Illig T, Xu CJ, Netea MG, Li Y. Nat Aging 5: 2025 607-621	13
A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID. Kumar S, Li C, Zhou L, Zhan Q, Alaswad A, Volland S, Costa B, Krooss SA, Klefenz I, Schmaus H, Zeuzem A, von Witzendorff D, Lickei H, Pueschel L, Kraft ARM, Cornberg M, Koczulla AR, Pink I, Hoeper MM, Xu CJ, Häussler S, Wiestler M, Netea MG, Illig T, Sun J, Li Y. Nat Immunol 27: 2026 200-212	1

Publications

Citations

Single-cell immune aging clocks reveal inter-individual heterogeneity during infection and vaccination.
Li W, Zhang Z, Kumar S, Botey-Bataller J, Zoodsma M, Ehsani A, Zhan Q, Alaswad A, Zhou L, Grondman I, Koeken V, Yang J, Wang G, Volland S, Crişan TO, Joosten LAB, Illig T, Xu CJ, Netea MG, Li Y. Nat Aging 5: 2025 607-621

A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID.
Kumar S, Li C, Zhou L, Zhan Q, Alaswad A, Volland S, Costa B, Krooss SA, Klefenz I, Schmaus H, Zeuzem A, von Witzendorff D, Lickei H, Pueschel L, Kraft ARM, Cornberg M, Koczulla AR, Pink I, Hoeper MM, Xu CJ, Häussler S, Wiestler M, Netea MG, Illig T, Sun J, Li Y. Nat Immunol 27: 2026 200-212