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Multi-omics characterisation of the response to stimulation in Long Covid patients

We stimulated immune cells of 15 patients (5 timepoints) with Long Covid with RPMI or P. Aeruginosa strains (4h stimulations).

Type: Transcriptome Sequencing
Archiver: European Genome-phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000000203	We generated 10X, droplet-based paired snRNAseq+snATACseq (Multiome) of the response to P. Aeruginosa or RPMI in patients suffering from Long Covid. In total, we included 15 patients. Single nuclei libraries are genetically multiplexed across donors, genotype files are available to enable demultiplexing. Phenotype sheets provide information of pools/donors as well as donor phenotype.	Illumina NovaSeq 6000	31

Publications	Citations
A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID. Kumar S, Li C, Zhou L, Zhan Q, Alaswad A, Volland S, Costa B, Krooss SA, Klefenz I, Schmaus H, Zeuzem A, von Witzendorff D, Lickei H, Pueschel L, Kraft ARM, Cornberg M, Koczulla AR, Pink I, Hoeper MM, Xu CJ, Häussler S, Wiestler M, Netea MG, Illig T, Sun J, Li Y. Nat Immunol 27: 2026 200-212	1

Publications

Citations

A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID.
Kumar S, Li C, Zhou L, Zhan Q, Alaswad A, Volland S, Costa B, Krooss SA, Klefenz I, Schmaus H, Zeuzem A, von Witzendorff D, Lickei H, Pueschel L, Kraft ARM, Cornberg M, Koczulla AR, Pink I, Hoeper MM, Xu CJ, Häussler S, Wiestler M, Netea MG, Illig T, Sun J, Li Y. Nat Immunol 27: 2026 200-212