Eribulin efficacy in platinum-resistant and refractory high-grade serous ovarian cancer patient-derived xenograft models

Objectives: To determine the potential of anti-microtubule agent (AMA) therapy (paclitaxel, vinorelbine and eribulin) in platinum-resistant or refractory (PRR) HGSC by assessing response in patient-derived xenograft (PDX) models of HGSC. Approach:We characterized a cohort of PRR HGSC PDX models generated from treatment naïve or postsystemic therapy specimens, representative of individuals with PRR HGSC in the clinic. Whole-exome sequencing was carried out on five PDX tumours and whole-genome sequencing was carried out on one patient tumour.

Type: Cancer Genomics
Archiver: European Genome-Phenome Archive (EGA)

2 Datasets

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Dataset ID	Description	Technology	Samples
EGAD50000000215	Exome sequencing of tumour PDX and matched patient blood	Illumina NovaSeq 6000	10
EGAD50000000217	Whole genome sequencing of patient tumour and blood	Illumina NovaSeq 6000	2