Clonal Evolution and Blastic Plasmacytoid Dendritic Cell Neoplasm - Two Cases

Here we present two case studies of sequential whole exome sequencing (WES) in patients, who both developed BPDCN throughout their medical history but primarily presented with lymphoid cancers (clonally related ALK-negative anaplastic large-cell lymphoma (ALCL) and T-lymphoblastic lymphoma (T-LBL)) and whose bone marrow at remission exhibited a CMML phenotype, from which in both cases BPDCN clones arose that subsequently became treatment refractory.

Type: Exome Sequencing
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000000309	Whole exome sequencing data was mapped to GRCh38 using bwa-mem2 as implemented in the nfcore sarek workflow.	Illumina NovaSeq 6000	13

Publications	Citations
Clonal evolution and blastic plasmacytoid dendritic cell neoplasm: malignancies of divergent hematopoietic lineages emerging from a common founding clone. Denker S, Künstner A, Schwarting J, Witte HM, Bernard V, Stölting S, Lohneis P, Kusch K, von Bubnoff N, Merz H, Busch H, Feller AC, Gebauer N. Leukemia 38: 2024 1858-1861	0