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Targeted capture, whole genome sequencing, and RNAseq to identify rearrangements in B-cell lymphomas

This study contains whole genome and custom targeted capture sequencing of mature B-cell lymphomas (DLBCL, FL, BL, HGBCL-DH-BCL2, HGBCL-DH-BCL6) to identify translocation breakpoints of common oncogene rearrangements (MYC, BCL2, BCL6). It is complemented by RNAseq data where available. Complete details are available in the publication Hilton et al, 2024, Blood. Capture sequencing: 357 samples; 364 unique libraries; cram file format aligned to hg38 Whole genome sequencing: 12 samples; 12 unique libraries; cram file format aligned to grch37 RNAseq: 257 samples; 257 unique libraries; fastq file format

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD50000000474 Illumina NovaSeq X 12
EGAD50000000489 Illumina HiSeq X 364
EGAD50000000496 Illumina NovaSeq X 257
Publications Citations
High-resolution architecture and partner genes of <i>MYC</i> rearrangements in lymphoma with DLBCL morphology.
Blood Adv 2: 2018 2755-2765
47
Motive and Opportunity: MYC rearrangements in high-grade B-cell lymphoma with MYC and BCL2 rearrangements-an LLMPP study.
Blood 144: 2024 525-540
2