CD79B expression in DLBCL

This study proposes a novel association between CD79B expression and cell-of-origin subtypes of DLBCL. Integrative single-cell analyses also revealed a distinct association between germinal center B-cell physiology and the pattern of CD79B expression, which is potentially a key explanation for the variable CD79B expression in DLBCL.

Type: Transcriptome Analysis
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000000538	Mononuclear cells were isolated as cell suspensions by dissociation in a BD Horizon™ Dri Tumor & Tissue Dissociation Reagent (BD Biosciences) using a gentleMACS dissociator (Miltenyi Biotec). A totalseq-C antibody cocktail (Biolegend) was used, and the cell suspensions were diluted to a concentration of 1,000 cells/μL. Library sequencing was performed using the NovaSeq6000 System (Illumina). The FASTQ files were aligned to the 10x provided reference genome using 10x Genomics Cell Ranger software v7.1.0 to create unique molecular identifier count tables of gene expression of the samples.	Illumina NovaSeq 6000	1

Publications	Citations
Single-cell and spatial characterization of plasmablast-like lymphoma cells in primary central nervous system lymphoma. Kobayashi H, Chijimatsu R, Naoi Y, Otani Y, Mizuta R, Fujii K, Ishida J, Murakami H, Ujiie H, Ikeuchi K, Urata T, Seike K, Fujiwara H, Asada N, Fujii N, Matsuoka KI, Sato Y, Maeda Y, Ennishi D. Blood Neoplasia 2: 2025 100058	1