Genomic landscape of metastases from 97 patients with metastatic urothelial carcinoma

Metastatic urothelial carcinoma (mUC) is a lethal cancer, with limited therapeutic options. Large-scale studies in early settings provided critical insights into the genomic and transcriptomic characteristics of non-metastatic UC. The genomic landscape of mUC remains however unclear. Whole exome (WES) and mRNA sequencing (RNA-seq) were performed on metastatic biopsies from 111 patients with mUC. Driver genomic alterations from mUC were comparable to primary UC (TCGA data).

Type: Cancer Genomics
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000000550	Data generated from three prospective institution-wide tumor sequencing studies (SHIVA01 [NCT01771458], MOSCATO-01 [NCT02613962], and MATCH-R [NCT02517892]) to analyze the genomic landscape of metastases from 97 patients with mUC by performing both whole exome sequencing (WES) and whole-transcriptome sequencing (RNA-seq)	unspecified	211

Publications	Citations
The genomic and transcriptomic landscape of metastastic urothelial cancer. Loriot Y, Kamal M, Syx L, Nicolle R, Dupain C, Menssouri N, Duquesne I, Lavaud P, Nicotra C, Ngocamus M, Lacroix L, Tselikas L, Crehange G, Friboulet L, Castel-Ajgal Z, Neuzillet Y, Borcoman E, Beuzeboc P, Marret G, Gutman T, Wong J, Radvanyi F, Dureau S, Scoazec JY, Servant N, Allory Y, Besse B, Andre F, Le Tourneau C, Massard C, Bieche I. Nat Commun 15: 2024 8603	0

Publications

Citations

The genomic and transcriptomic landscape of metastastic urothelial cancer.
Loriot Y, Kamal M, Syx L, Nicolle R, Dupain C, Menssouri N, Duquesne I, Lavaud P, Nicotra C, Ngocamus M, Lacroix L, Tselikas L, Crehange G, Friboulet L, Castel-Ajgal Z, Neuzillet Y, Borcoman E, Beuzeboc P, Marret G, Gutman T, Wong J, Radvanyi F, Dureau S, Scoazec JY, Servant N, Allory Y, Besse B, Andre F, Le Tourneau C, Massard C, Bieche I. Nat Commun 15: 2024 8603