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Excised DNA Circles from V(D)J Recombination Promote Relapsed Leukaemia

In this study, we show that ecDNAs generated from V(D)J recombination replicate and persist through many cell generations. High ecDNA copies at diagnosis of B-cell precursor acute lymphoblastic leukaemia strongly correlate with subsequent relapse.

Type: Cancer Genomics
Archive: European Genome-phenome Archive (EGA)

1 Dataset

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000000590	This datasets include LamESC and LamREC raw sequencing data obtained from 76 B-cell precursor acute lymphoblastic leukaemia patients.	unspecified	129