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Excised DNA Circles from V(D)J Recombination Promote Relapsed Leukaemia

In this study, we show that ESCs replicate and persist through many cell generations. High ESC copies at diagnosis of BCP-ALL strongly correlate with subsequent relapse. These data provide the first demonstration that the V(D)J recombination by-product, when replicated to elevated levels, potently associates with the V(D)J recombinase to cause adverse disease outcomes.

Type: Cancer Genomics
Archiver: European Genome-phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000000597	This dataset includes all data produced in the study describing "Lam-ESC&Lam-Recombination", a method for sequencing of signal joints and coding joints generated from human light chain antigen receptor loci during V(D)J recombination in B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) patients. This dataset includes: - Amplicon Lam-ESC for a total of 86 BCP-ALL patients - fastq files - Amplicon Lam-Recombination for a total of 43 BCP-ALL patients - fastq files	unspecified	129

Publications	Citations
Excised DNA circles from V(D)J recombination promote relapsed leukaemia. Gao Z, Scott JNF, Edwards MP, Casey D, Wang X, Gillen AD, Ryan S, Russell LJ, Moorman AV, de Tute R, Cargo C, Ford AM, Westhead DR, Boyes J. Nature 645: 2025 774-783	1