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snRNA and snATAC analysis of cocaine use disorder in human caudate nucleus

We investigated cell type specific changes of gene expression and chromatin accessibility in the caudate nucleus of N=6 individuals with and N=8 individuals without cocaine use disorder using postmortem human brain samples. We performed single-nuclei RNA-sequencing and single-nuclei ATAC sequencing in the same cells using the 10xMultiome platform. The N=14 tissue donors were of African-American ancestry. The cohort consists of N=5 female and N=9 male individuals.

Type: Gene Regulation Study
Archiver: European Genome-phenome Archive (EGA)

1 Dataset 2 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000000691	The dataset contains raw data from 10x Multiome derived single-nuclei RNA and single-nuclei ATAC sequencing in the same cells	Illumina NovaSeq 6000	14

Publications	Citations
Development of a fully human glioblastoma-in-brain-spheroid model for accelerated translational research. Horschitz S, Jabali A, Heuer S, Zillich E, Zillich L, Hoffmann DC, Kumar AS, Hausmann D, Azorin DD, Hai L, Wick W, Winkler F, Koch P. J Adv Res 79: 2026 363-377	2
Cell type-specific multi-omics analysis of cocaine use disorder in the human caudate nucleus. Zillich L, Artioli A, Pohořalá V, Zillich E, Stertz L, Belschner H, Jabali A, Frank J, Streit F, Avetyan D, Völker MP, Müller S, Hansson AC, Meyer TD, Rietschel M, Ladewig J, Spanagel R, Oliveira AMM, Walss-Bass C, Bernardi RE, Koch P, Witt SH. Nat Commun 16: 2025 3381	4