cfDNA methylation profiling on longitudinally collected blood plasma of patients with esophageal adenocarcinoma

Esophageal adenocarcinoma (EAC) is an aggressive cancer characterized by a high risk of relapse post-surgery. Analyzing cell-free DNA (cfDNA) from blood plasma emerges as a promising avenue for therapy response monitoring. This study aims to evaluate the cost-effective and genome-wide cell-free reduced representation bisulfite sequencing (cfRRBS) method combined with computational deconvolution for effective disease monitoring in EAC patients.

Type: Epigenetics
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset

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Dataset ID	Description	Technology	Samples
EGAD50000000734	cell-free Reduced Representation Bisulfite Sequencing (cfRRBS) data from blood plasma and FFPE tissue samples from patients with esophageal adenocarcinoma, and blood plasma of healthy donors.	Illumina NovaSeq 6000	207