Stratified Medicine Paediatrics (SMPaeds): molecular profiling of relapsed paediatric cancer

We profiled a large heterogenous cohort of matched diagnostic-relapse tumour tissue and plasma-derived cell free DNA (cfDNA) from patients with relapsed and progressive solid tumours of childhood. Tumour DNA and cfDNA were analysed by targeted panel sequencing and low coverage whole genome sequencing.

Type: Cancer Genomics
Archiver: European Genome-Phenome Archive (EGA)

4 Datasets

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000000781	Deep sequencing of a targeted panel of 67 paediatric cancer related genes for cfDNA with UMIs at approximately 1500xUMI coverage.	Illumina NovaSeq 6000	404
EGAD50000000782	Low coverage whole genome sequencing (0.5-4X) for cfDNA collected from blood plasma.	Illumina NovaSeq 6000	477
EGAD50000000783	Deep sequencing of a targeted panel of 92 paediatric cancer related genes or 233 pan-cancer related genes for both relapse/archival disgnostic tumour tissue and germline DNA from whole blood cell pellet. Tumour tissue was sequenced to approximately 400X coverage and germline DNA was sequences to aproximately 100X coverage.	Illumina NovaSeq 6000	1149
EGAD50000000784	Low coverage whole genome sequencing (0.5-4X) for both relapse and archival diagnostic tumour tissue.	NextSeq 500	586