Subclonal variation in patients with pediatric T-lymphoblastic leukemia (T-ALL)

Variations in TP53 and KRAS genes indicate a particularly poor prognosis in relapsed pediatric T-ALL. We hypothesized that these variations might be subclonally present at disease onset and contribute to relapse risk. To test this, we examined 386 children diagnosed with T-ALL, including more than 100 patients who relapsed as well as matched non-relapsing controls.

Type: Cancer Genomics
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

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Dataset ID	Description	Technology	Samples
EGAD50000001168	Targeted deep sequencing data of 386 T-ALL patients in several high-risk T-ALL genes. Samples were prepared according to Agilent's HaloPlex HS Target Enrichment Protocol and sequenced as 75bp paired-end reads. Data is available as paired-end FASTQ files for each sample.	NextSeq 2000	386

Publications	Citations
Subclonal TP53 and KRAS variants combined with poor treatment response identify ultrahigh-risk pediatric patients with T-ALL. Kempter T, Richter-Pechańska P, Michel K, Rausch T, Erarslan-Uysal B, Eckert C, Zimmermann M, Stanulla M, Schrappe M, Cario G, Köhrer S, Attarbaschi A, Korbel JO, Kunz JB, Kulozik AE. Blood Adv 9: 2025 1267-1279	1