Clonal Evolution of PPM1D Mutations in the Spectrum of Myeloid Disorders

PPM1D, a central regulator of the DNA damage response, is commonly mutated in therapy-related clonal hematopoiesis (CH), acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). PPM1D mutations have been shown to expand under selective pressure of DNA-damaging chemotherapy. However, whether PPM1D mutations promote the development of hematologic malignancies remains unclear.

• Type: Cancer Genomics
• Archiver: European Genome-Phenome Archive (EGA)