Acute lymphoblastic leukemia in children produces endogenous T-cells targeting tumor associated antigens and neoantigens in peripheral blood

In this study we investigated the presence of endogenous T-cells recognizing private tumor-associated antigens and predicted neoantigens. To this end, HLA-I and HLA-II restricted tumor associated antigens (TAAs) and neoantigens were respectively identified and predicted from matched tumor and germline (PBMCs) in three acute lymphoblastic leukemia patients. Circulating T-cells targeting both Mass spectrometry (MS)-identified TAAs and predicted neoantigens were identified in virtually all pediatric BCP-ALL patients, extending up to two years on remission.

Type: Exome Sequencing
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000001355	This dataset includes illumina paired-end reads (fastq) of whole-exome sequencing (WES) data from three acute lymphoblastic leukemia patients. Tumor samples were obtained from patients, each with matched patient’s peripheral blood mononuclear cells (PBMCs). PBMCs are provided as a germline reference.	Illumina MiniSeq	6

Publications	Citations
Circulating tumor-associated and neoantigen-specific endogenous T cells in children treated for B-acute lymphoblastic leukemia. Huwiler E, Thierry AC, Michaux J, Pak H, Huber F, Arber C, Bassani-Sternberg M, Harari A, Ceppi F. Hemasphere 9: 2025 e70171	0