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Transcriptome analysis of 32 pheochromocytoma and paraganglioma samples

Pheochromocytomas and sympathetic paragangliomas (PPGL) are rare neuroendocrine tumors derived from chromaffin tissue of the adrenal medulla and sympathetic paraganglia, respectively. There is at the moment a lack of accurate biomarkers to predict the biologic behavior of a PPGL. The aim of this study was to investigate the biological behavior of localized and metastatic PPGL by comparing the genomic and transcriptomic landscapes of localized and metastatic PPGL, including PPGL samples with a non-metastatic phenotype at initial diagnosis that developed metachronous metastases during follow-up. The dataset presented here contains the RNA-seq data of 32 tumor samples (n=17 localized, n=15 metastatic).

Type: RNASeq
Archive: European Genome-phenome Archive (EGA)

1 Dataset

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Dataset ID	Description	Technology	Samples
EGAD50000001447	This dataset contains RNA-seq data of 32 pheochromocytoma and paraganglioma samples (n=17 localized, n=15 metastatic). A NEXTflex Rapid Directional qRNA library preparation kit (Perkin Elmer) was used for RNA quantification. Samples were sequenced on a NextSeq 500 sequencer (Illumina). The files have the FASTQ format (paired; 2 x 32 files).	NextSeq 500	32