Genetic differences between primary colorectal cancer and its paired synchronous and metachronous metastases

In this study we present for the first time the genetic differences associated with different chronicity of colorectal cancer liver metastases identified by whole-exome sequencing of 210 CRC samples. We focus on differences in primary tumors as we hypothesize that these are the cause of the differences in the time course of the disease. The results suggest that distinct tumor progression pathways account for different chronicity outcomes with ultimate impact on patient’s prognosis

Type: Exome Sequencing
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

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Dataset ID	Description	Technology	Samples
EGAD50000001460	This study contains data obtained from 210 CRC samples (87 pairs and 36 singletons for whom only one of the sample pair was available). Our sample set consisted of 105 primary tumor and 105 metastatic samples. Data are analysis-ready BAM files. Sequencing libraries were prepared with the SureSelect Human All Exon V8 kit by Agilent. Sequencing was done on NovaSeq X Plus instrument (Illumina, San Diego, CA, USA) using 150-bp paired-end reads.	Illumina NovaSeq 6000	210

Publications	Citations
Genetic differences between primary colorectal cancer and its paired synchronous and metachronous metastases. Rajtmajerova M, Ambrozkiewicz F, Hlavac V, Trailin A, Cervenkova L, Bruha J, Susova S, Soucek P, Vodicka P, Vodickova L, Kubecek O, Filip S, Mallela VR, Ye W, Zitricky F, Liska V, Hemminki K. Int J Cancer 158: 2026 120-130	1